Medical News Today: Colorectal Cancer News
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Updated: 19 hours 9 min ago
Among patients who had undergone curative surgery for primary colorectal cancer, the screening methods of computed tomography and carcinoembryonic antigen each provided an improved rate of surgical treatment of cancer recurrence compared with minimal follow-up, although there was no advantage in combining these tests, according to a study in the January 15 issue of JAMA.
A new method for analysing biological samples based on their chemical makeup is set to transform the way medical scientists examine diseased tissue.When tests are carried out on a patient's tissue today, such as to look for cancer, the test has to be interpreted by a histology specialist, and can take weeks to obtain a full result.
In a large study of women's health, postmenopausal women who followed a healthy lifestyle were at a third lower risk of death, including a 20% smaller chance of dying from cancer, than women who did not follow guidance on diet, weight, physical activity, and alcohol intake.
Researchers at Cleveland Clinic have developed a new tool called CRC-PRO that allows physicians to quickly and accurately predict an individual's risk of colorectal cancer, as published in the current edition of the Journal of the American Board of Family Medicine.
European Commission approves update of Erbitux metastatic colorectal cancer labeling to patients with RAS wild-type tumors
Merck Serono, the biopharmaceutical division of Merck, has announced that the European Commission has approved the Type II variation to amend the Erbitux® (cetuximab) product information, updating the indication for Erbitux to the treatment of patients with RAS wild-type metastatic colorectal cancer (mCRC).
A University of Colorado Cancer Center study published online ahead of print in the journal Molecular Cancer Research shows that ALK and ROS1 gene rearrangements known to drive subsets of lung cancer are also present in some colorectal cancers. These results imply that drugs used to target ALK and ROS1 in lung cancer may also have applications in this subset of colorectal cancer patients.
The epidermal growth factor receptor (EGFR) is expressed in normal colonic cells and is activated by specific peptide growth factors that regulate cell proliferation, survival and differentiation. Increased expression and activation of the EGFR has been observed in the majority of colorectal carcinoma (CRC), suggesting that the EGFR pathway plays an important role in colon carcinogenesis.
The Annual Report to the Nation on the Status of Cancer, covering the period 1975-2010, showed death rates for lung cancer, which accounts for more than one in four cancer deaths, dropping at a faster pace than in previous years.
A tiny, transparent fish embryo and a string of surprises led scientists to a deeper understanding of the perplexing link between low calcium and colon cancer.By studying zebrafish embryo skin, University of Michigan researchers decoded cell messages underlying abnormal colonic cell growth of the kind that can lead to tumors and colon cancer in calcium deficient individuals.
MRI assessment of rectal cancer provides crucial prognostic information to improve survival for patients
Research published in this month's Journal of Clinical Oncology found that pre-op MRI assessment is crucial in helping to inform a more advanced treatment approach for rectal patients by predicting local recurrence and disease-free survival.Rectal cancer currently accounts for one third of all colorectal cancers and is a leading cause of cancer death in the Western World.
Queen's University has announced it is to lead a €6 million European study to find new treatments for bowel cancer.The research, which involves 13 partners in eight different European countries, will look at two major genetic factors which make bowel cancer difficult to treat.Bowel cancer, also known as colorectal cancer, is the second major cause of cancer mortality.
In one of the largest epidemiological studies of human gut bacteria and colorectal cancer ever conducted, a team of researchers at NYU Langone Medical Center has found a clear association between gut bacteria and colorectal cancer.
Human papillomavirus, or HPV, which can cause cervical cancer in women, is also known to cause anal cancer in both women and men. Now, a study led by researchers at the UCLA School of Nursing has found that older HIV-positive men who have sex with men are at higher risk of becoming infected with the HPVs that most often cause anal cancer.
For the first time, researchers at Umea University have succeeded in showing how the DNA polymerase epsilon enzyme builds new genomes. The detailed image produced by these researchers shows how mutations that can contribute to the development of colorectal cancer and cervical cancer lead to changes in the structure of the protein.
Scientists and surgeons at Princess Margaret Cancer Centre have discovered a promising new approach to treating colorectal cancer by disarming the gene that drives self-renewal in stem cells that are the root cause of disease, resistance to treatment and relapse. Colorectal cancer is the third leading cause of cancer-related death in the Western world.
Researchers in Canada found that switching off a gene in the cancer stem cells that drive colon cancer stops them from being able to renew themselves. They say their study offers a starting point to treatments that could shut the cancer down.Cancer stem cells are cells that have the ability to differentiate into all the types of cell that exist in that type of tumor.
The protein in cells that most often drives the development of cancers has eluded scientists' efforts to block it for three decades - until now.Using a new strategy, UC San Francisco researchers have succeeded in making small molecules that irreversibly target a mutant form of this protein, called ras, without binding to the normal form.
Researchers at the University of California, San Diego School of Medicine say metastatic colorectal cancer patients of African-American descent are less likely to be seen by cancer specialists or receive cancer treatments. This difference in treatment explains a large part of the 15 percent higher mortality experienced by African-American patients than non-Hispanic white patients.
New results are in from the Women's Health Initiative (WHI) Calcium plus Vitamin D Supplementation Trial. These findings assess the effects on hip fracture and colorectal cancer incidence among 30,000 postmenopausal women nearly five years after the seven-year period of calcium plus vitamin D supplementation ended.